Diagnostic endoscopic mucosal resection is useful for diagnosing rectal tonsil

Dai Nakamatsu, Masashi Yamamoto, Tsutomu Nishida

Toyonaka Municipal Hospital, Osaka, Japan

Department of Gastroenterology, Toyonaka Municipal Hospital, Osaka, Japan

Correspondence to: Tsutomu Nishida, MD, Department of Gastroenterology, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, Osaka 560-8565 Japan, e-mail: tnishida.gasatro@gmail.com
Received 11 April 2018; accepted 14 April 2018; published online 25 May 2018
DOI: https://doi.org/10.20524/aog.2018.0277
© 2018 Hellenic Society of Gastroenterology

Annals of Gastroenterology (2018) 31, 520-520


Rectal tonsil is a rare disease involving a reactive proliferation of lymphoid tissue in the rectum. It is a benign lymphoid hyperplasia of the rectum, difficult to differentiate from lymphomas, in particular mucosa-associated lymphoid tissue [1,2], by biopsy specimen.

A 52-year-old woman with hematochezia visited our hospital. Colonoscopy showed submucosal tumors of multiple and variable size in the lower rectum, with a worm-like shape. A biopsy specimen suggested malignant lymphoma. Her soluble interleukin-2 receptor level was within the normal range (Fig. 1A). Magnifying endoscopy with narrow-band imaging showed an absence of surface structure and the presence of regular-caliber branching microvessels. Endoscopic ultrasound revealed homogeneous, hypoechoic thickening of the lamina propria with a clear border from the submucosal layer (Fig. 1B). We performed re-biopsies from lesions, which showed lymphocytes slightly infiltrated into the ducts, but lymphoepithelial lesions were not observed and a definitive diagnosis of lymphoma could not be reached. Accordingly, we performed an endoscopic mucosal resection (EMR) to get an en bloc specimen for definitive diagnosis. This specimen revealed that the tumors were composed of a great proliferation of lymph follicles whose germinal center was in the lamina propria (Fig. 2A). A large lymph follicle squeezed the normal ducts, but no findings of malignant lymphoma with destruction of normal duct structure or lymphoepithelial lesions were seen (Fig. 2B). Flow cytometry from the specimen by EMR showed polyclonal B cell proliferation, while a genetic test also showed no abnormality. Finally, we diagnosed her condition as rectal tonsil.

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Figure 1 (A) Colonoscopy showed submucosal tumors of multiple and variable size in the lower rectum, with a worm-like shape. (B) Endoscopic ultrasound revealed homogeneous, hypoechoic thickening of the lamina propria with a clear border from the submucosal layer

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Figure 2 (A) The macroscopic specimen obtained by endoscopic mucosal resection revealed that the tumors were composed of a great proliferation of lymph follicles whose germinal center was in the lamina propria. (B) A large lymph follicle squeezed the normal ducts, but no findings of malignant lymphoma with destruction of normal duct structure or lymphoepithelial lesions were seen

References

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2. Shepherd NA, Hall PA, Coates PJ, Levison DA. Primary malignant lymphoma of the colon and rectum. A histopathological and immunohistochemical analysis of 45 cases with clinicopathological correlations. Histopathology 1988;12:235-252.